Cisplatin apoptosis induction

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August undefined, 2024

WebApr 28, 2011 · Furthermore, in agreement with a previous report, the apoptosis induced by cisplatin is dependent on the cell cycle. Indeed, cell death by apoptosis is significantly inhibited in nonproliferating cells (Fig. 5; ... Retinoid-related molecules require caspase 9 for the effective release of Smac and the rapid induction of apoptosis, ... WebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts …

Requirement for ERK Activation in Cisplatin-induced Apoptosis*

WebWe previously described that blocking ALDH activity enhances the induction of apoptosis, especially in ovarian cancer stem cells treated with chemotherapeutic agents. ... In combination with DSF and cisplatin, relatively more apoptosis and necrosis were induced in cisplatin-resistant cells than in their parental cells (apoptosis and necrosis ... WebCisplatin-induced testicular damage is a major obstacle in the application of cisplatin as chemotherapeutic agent. However, it remains as one of the most widel 掌桥科研一站式科研服务平台 list of common app schools

Cisplatin-induced apoptosis proceeds by caspase-3-dependent …

WebJun 1, 2007 · To investigate whether paeonol (Pae) has synergistic effects with cisplatin (CDDP) on the growth-inhibition and apoptosis-induction of human hepatoma cell lines HepG2 and SMMC-7721. Methods:... WebMay 10, 2013 · Chemotherapeutic drugs like cisplatin are known to act by inducing apoptosis. During apoptosis, a structurally related group of cysteine proteases known as caspases mediate protein cleavage [ 6, 7 ]. Caspases can be classified into two groups, more precisely initiator and effector caspases. WebApr 2, 2024 · In our results, the group with cisplatin delivery-based electrospray (CDES) at 6 kV had an apoptosis of cancer cells approximately two times more than the group treated with cisplatin alone. images party

Cisplatin-induced apoptosis in auditory cells: role of death …

Profiling of signaling molecules in four different human …

WebWe have shown previously that β-elemene increases cisplatin cytotoxicity and enhances cisplatin sensitivity via blocking cell cycle progression at G2/M phase in resistant ovarian tumor cells. In the current study, we asked whether β-elemene-augmented cisplatin activity in ovarian carcinoma cells is mediated through the induction of apoptosis. WebAutophagy induction in cisplatin-treated cells was preceded by activation of adenosine monophosphate-activated protein kinase (AMPK) and concomitant down-regulation of mammalian target of rapamycin (mTOR)-mediated phosphorylation of p70S6 kinase. images paint brushes in containersWebCisplatin is the most important and efficacious chemotherapeutic agent for the treatment of advanced gastric cancer. Cisplatin forms inter- and intrastrand crosslinked DNA adducts … images party hats

"WebCisplatin was found to be more cytotoxic to A172 than T98G cells in a time- and concentration-dependent manner. Cisplatin-induced cytotoxicity manifested as apoptosis, characterized by genomic DNA fragmentation, nuclear condensation and … " - Cisplatin apoptosis induction

Cisplatin apoptosis induction

Expression of p53, Bcl-2 and Bax in cisplatin-induced apoptosis in ...

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … WebJun 13, 2014 · In ovarian cancer cells that have developed acquired cisplatin resistance, both ERK activation and autophagy induction are increased. Importantly, knockdown of ERK or inhibition of autophagy promotes cisplatin-induced apoptosis in …

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WebApr 7, 2016 · Tubular cell apoptosis plays an essential pathogenic role for cisplatin-induced AKI. In this study, cell apoptosis was examined by terminal deoxynucleotidyl transferase-mediated digoxigenin-deoxyuridine nick-end labeling (TUNEL) staining and immuno-staining for cleaved caspase 3 in kidney tissues. WebThe manuscript by Bernardo-Bermejo analyses the metabolic differences between apoptotic bodies released by HK-2 cells, upon induction to apoptosis either by cisplatin or UV light. Although the topic may be potentially of interest, the manuscript is unclear, as well as the main findings. In addition, some methodological issues need to be addressed.

WebIn this study, cisplatin was found to induce apoptosis in a cochlear cell line, in a dose- and duration-dependent manner. Specific caspase assays revealed an early (6 h) but transient increase in caspase 8 activity, and a delayed (12 h) increase in caspase 9 activity. The enhanced caspase 8 activity was preceded by upregulation of p53 ... WebOct 13, 2024 · Cisplatin is an inorganic platinum derivative that is widely used for chemotherapy of various solid tumours. In cancer cells, cisplatin induces DNA crosslinks and DNA adducts, triggering the...

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant …

WebNext, post-target resistance mechanisms preventing induction of apoptosis by cisplatin were studied in LTTs. The mRNA expression of the apoptotic regulators BCL-xL, BCL …

WebWe have treated four prostate tumor cell lines, DU-145, PC-3, LNCaP and 22RV1 with various concentrations of cisplatin in order to check for influence on viability and for … images party dresses young girlsWebFor all four cell lines, the induction of apoptosis by cisplatin correlated with drug sensitivity in the MTT assay. The differences in chemosensitivity and induction of apoptosis could not be attributed to differences in cellular platinum accumulation, DNA platination or platinum-DNA adduct removal. images party busWebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in … images partyingWeb1 day ago · Pomiferin suppresses apoptosis-resistant cells via induction of autophagy-dependent cell death. (A) ... Pomiferin potentiates the tumor suppression effect of … list of common birth defectsWebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis … images partners city of orangeWebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for treatment of human cancers. However, a major limitation of CDDP chemotherapy is serious drug resistance. images party noelWebAug 30, 2024 · Cisplatin-induced apoptosis and necroptosis were also effectively suppressed by melatonin in mouse renal tubular epithelial (TCMK-1) cells. These results reveal a novel mechanism underlying the therapeutic effect of the hormone against cisplatin-induced AKI. ... resulting in induction of cytochrome c release into cytosol and … list of common benzodiazepine