Rnf4 sumo

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August undefined, 2024

WebRNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation. Nature Cell Biology, 10(5), 538–546. doi:10.1038/ncb1716 10.1038/ncb1716 WebApr 8, 2014 · The recognition of chromatin bound SUMO conjugates via its intrinsically disordered amino terminus acts as a primary “latch” for RNF4 recruitment 24 26. …

RNF4-Dependent Hybrid SUMO-Ubiquitin Chains Are Signals for

WebSep 30, 2024 · The SUMO-Targeted Ubiquitin Ligases (STUbL) mediate this process, and RNF4, the mammalian STUbL, has been at the forefront in the understanding of this … WebCompartmentalization of the SUMO/RNF4 pathway by SLX4 drives DNA repair. In this study, Alghoul et al. show that the Fanconi anemia protein SLX4 forms globular clusters of … tryimg

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WebSUMOylated chromatin modifiers include JARID1B/KDM5B, JARID1C/KDM5C, p300, CBP, PARP1, SetDB1, and MBD1. Whereas SUMOylated JARID1B was ubiquitylated by the SUMO-targeted ubiquitin ligase RNF4 and degraded by the proteasome in response to DNA damage, JARID1C was SUMOylated and recruited to the chromatin to demethylate histone … Web深入研究「Structural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain」主題。共同形成了獨特的指紋。排序方式重量按字母排序 Medicine & Life Sciences. Proteins 89%. Small Ubiquitin-Related Modifier Proteins … WebEnseignement Introduction Si la régulation de l’expression des gènes est un aspect essentiel du développement, celle-ci fait également partie intégrante de la transformation cancéreuse. La transcription des gènes fait l’objet de multiples régulations dont les grands principes ont été rappelés. Le cours a ensuite été centré sur l’étude détaillée d’un facteur de ... philking.com

Sumo-targeted ubiquitin ligase RNF4 regulates the localization …

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http://genesdev.cshlp.org/content/26/11/1179 WebArsenic degrades PML or PML/RARA via a sumo-triggered RNF4/ubiquitin-mediated pathway. Nature Cell Biology mai 2008 RXR is an essential component of the oncogenic PML/RARA complex in vivo. Cancer Cell juil. 2007 Dimerization-induced ... try image of land on sideWebFunction. E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of … try in a court crossword

"WebJan 27, 2024 · We show herein that Rnf4, an E3 ubiquitin ligase that targets SUMO-modified proteins, accumulates in DSB repair foci and is required for both homologous … " - Rnf4 sumo

Rnf4 sumo

WebHirota K, Tsuda M, Murai J, Takagi T, Keka IS, Narita T, Fujita M, Sasanuma H, Kobayashi J, Takeda S SUMO-targeted ubiquitin ligase RNF4 plays a critical role in preventing chromosome loss. Genes Cells 19: 743-54 (2014) WebExcept these studies, I was also involved in solving structures of SUMO chain, type II topoisomerase and transglycosylase in complex with chemical compounds. During few …

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WebJun 17, 2024 · A tag already exists with the provided branch name. Many Git commands accept both tag and branch names, so creating this branch may cause unexpected behavior. WebMar 20, 2014 · A segmental labelling approach combined with solution nuclear magnetic resonance (NMR) spectroscopy and biochemical characterization is used to reveal how …

WebWe show herein that Rnf4, an E3 ubiquitin ligase that targets SUMO-modified proteins, accumulates in DSB repair foci and is required for both … WebPublication Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4. Xu Y, Plechanovova A, Simpson P, Marchant J, Leidecker O, Kraatz S, Hay RT, …

WebThe SIM domain contains the four SUMO interaction motifs (SIMs) of RING-finger 4 (RNF4). This SIM domain prefers binding polySUMO chains with four or more SUMOs. It is useful for enrichment of polysumolyated proteins or polySUMO chains. 基 … WebSep 30, 2024 · While RNF4 is a SUMO-targeted ubiquitin ligase, protein stabilization requires the substrate’s phosphorylation, rather than SUMOylation, and binding to RNF4’s arginine …

WebHowever, Iyer et al 57 revealed that, in vitro and in cultured cells, PIM-1 was modified by the small ubiquitin-like modifier (SUMO), and SUMOylation promoted the ubiquitin-mediated …

WebJan 26, 2024 · Our results indicate that the SUMO-2 preferential trap improved the enrichment of SUMO2 conjugates compared to the RNF4 SIM-based trap. A SIM in XRCC4 … phil kiner websiteWebHowever, in the presence of SUMO chains, RNF4 is activated by dimerization, leading to both substrate ubiquitylation and autoubiquitylation, responsible for degradation of RNF4. Thus … phil king christian singerWebStructural analysis of poly-SUMO chain recognition by the RNF4-SIMs domain. C. Kung, M. Naik, +7 authors Tai-Huang Huang; Biology ... try in absentiaWebJun 29, 2010 · Here we show that RNF4 (RING finger protein 4), a SUMO-dependent ubiquitin E3-ligase previously implicated in maintaining genome stability, plays a key role in active … try imvu for freeWebPML targeting eradicates quiescent leukaemia-initiating cells. PHLPP: A Phosphatase that Directly Dephosphorylates Akt, Promotes Apoptosis, and Suppresses Tumor Gr... Role of PML in Cell Growth and the Retinoic Acid Pathway. Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor. tryinWebSep 18, 2024 · Similarly, RNF4 has been shown to regulate the SUMO- and ubiquitin-mediated proteasomal degradation of a mutant cystic fibrosis transmembrane … phil king district 61WebFeb 3, 2014 · Knockdown of the E3 ligase RNF4, which synthesizes hybrid SUMO-ubiquitin linkages, prevented efficient recruitment of RAP80 and BRCA1 to sites of DNA damage … phil king mediation